Sleeping Aid With Rohypnol Flunitrazepam | OZISIK ECZANE
Rohypnol Flunitrazepam is a sedative benzodiazepine with important therapeutic usefulness and significant abuse liability. Its capability to induce anterograde amnesia favors Rohypnol use as a “date-rape drug” administered often at a bar or party (“club drug”) by adding it unknowingly to the drinks of victims who will have limited memory of the assault. On the contrary, on the illicit market, Flunitrazepam may be fake products that do not contain that substance. Rohypnol Flunitrazepam combined with anesthetics, opioids, ethanol, cocaine, and methamphetamine can occur in therapeutic use and in polydrug abuse. Flunitrazepam action mechanism involves its binding to the γ-aminobutyric acid receptor (GABAA-R), an intrinsic membrane protein. Changes in the binding site structure by allosteric binding of another drug or by affecting lipid phase dynamics in a receptor's surroundings can modulate this binding activity. Thus, Rohypnol Flunitrazepam–GABAA-R binding...